| Annihilation Anew
| Begin Date
| End Date
|| Annihilation Alternate Universe
|| Tat, Tez
|| Kade, Talya, Ciel, Rohan, Tiffany, Moody, Maxim, Christian, Rosalie, Orianne, Kaylee, Jeremy, Richard, Alexandra, Eleanor, Sumit, Vega, Valerie, Alistair, Irene, Diego, Micaela, Arturo, Zoe, Reya, Samad, Huruma, Carol, Solomon
| Important NPCs
|| Robert Rider, Gamora, Ravenous, Annihilus
Something is knocking on the door between dimensions. X-Factor answers it - whether they want to or not.
- June 9 - Richard (and Christian) are kidnapped by Ravenous and taken to an alternate universe.
- June 10 - An emergency meeting is called at X-Factor HQ. Gamora crashes it, enlists XFS to help rescue Richard, and transports them into an alternate universe...in space.
- June 11 - Some members of X-Factor are captured back on Earth and taken to the AU against their will, where they are locked up as hostages. Meanwhile, Richard escapes his captor and the rest of X-Factor finds out about those who were captured.
- June 12 - X-Factor performs a successful jailbreak to get their captured co-workers out. But the portal device that got most of them to the AU is broken in the process, trapping everyone in space.
- June 14 - Another meeting is called, this time by Gamora. With the portal device broken, X-Factor is tasked with finding another by way of finding Annihilus' ship. The best place to find that information is on this universe's Earth. X-Factor members are set to training for conflict and given the option to augment their mutations.
- June 20 - X-Factor lands on alternate Earth, where they are almost immediately tracked by Hounds. Before the Hounds arrive, they are picked up by a local resistance group and taken a secret bunker.
- June 26 - X-Factor deploys three teams to the primary Seeker base on Staten Island. One sneaks into the command center to gain intel on the location of Annihilus's ship, the second steals a spaceship from the nearby spaceport, and the third holds a rendezvous location again swarms of bugs.
- Team One injuries: None!
- Team Two injuries: Kade (broken left arm), Jeremy (lacerations & bruising to abdomen), Kaylee (concussion & bruising), Vega (broken leg)
- Team Three injuries: Eleanor (light psychic trauma??), Tiffany (non-light psychic trauma), Christian (gash on ribcage), Micaela (concussion & gash on right leg)
- July 1 - X-Factor launches a final attack on Annihilus's fleet and base on Xandar. In the end, Annihilus and several of his queens are destroyed, which brings a total breakdown of his swarms. Almost immediately, Ravenous sues for peace, and the start of the rebuilding process begins.
- Space Team injuries:
- Xandar Team injuries:
Annihilus is defeated by X-Factor, and his armies fall with him. With the Cosmic Control Rod in hand, the teleporter technology is able to be restored to open rifts back to X-Factor's Earth for them to return to.
- 2046-07-01 After Effects (Vega, Samad, Irene)
- 2046-07-12 Maternal Concern (Alistair)
- 2046-07-05 Spiraling (Ciel)
- 2046-07-01 Returning Heroes (Irene, Huruma)
- 2046-07-09 Questioning (Jeremy, Reya, Irene, Eleanor, Micaela, Huruma, Rohan)
- 2046-07-01 Infinite Power (Vega)
- 2046-07-09 Home (Irene)
- 2046-07-10 Yo Cuz (Reya, Santos)
- 2046-07-03 Lost (Ciel, Richard, Alistair)
- 2046-07-09 The Nature of Parenthood (Eleanor)
- ... further results
- 2046-07-01 The Liberation of Xandar (Richard, Rohan, Lea, Huruma, Reya, Solomon, Jeremy)
- 2046-07-09 Homeward Bound (X-Factor)
- 2046-07-01 Aboard the Destroyer (Irene, Diego, Orianne, Kade)
- 2046-06-29 Left Behind (Richard)
- 2046-06-26 Bada BOOM (Kade, Richard, Vega, Irene, Kaylee, Solomon, Jeremy)
- ... further results